UCMI NEWS
UCMI modified mosquito biting demonstration – the UCD team conducted a laboratory demonstration to evaluate the human response to the bite of the modified mosquito.
UCMI SCIENTIFIC REPORTS & PUBLICATIONS
Find information here about the malaria research that the UCMI team has published.
- Abundance of conserved CRISPR-Cas9 target sites within the highly polymorphic genomes of Anopheles and Aedes mosquitoes. / Schmidt H.(2020)
- Experimental population modification of the malaria vector mosquito, Anopheles stephensi. / Pham TB (2019)
- Population modification of Anopheline species to control malaria transmission. / Carballar-Lejarazú, R (2018)
- Two lines of research converge to create immunizing gene-drive mosquitoes. / Bier E. (2017)
- Highly efficient Cas9-mediated gene drive for population modification of the malaria vector mosquito Anopheles stephensi. /Gantz VM et al (2015)
- Evaluation of potential field trial sites for the release of genetically engineered mosquitoes. Hanemaaijer MJ et al (2018)
- Gene Drives and Active Genetics in The Biomedical & Life Sciences Collection, Henry Stewart Talks.
- Engineered Resistance to Plasmodium falciparum Development in Transgenic Anopheles stephensi / Isaac et al (2011)
- Transgenic Anopheles stephensi coexpressing single-chain antibodies resist Plasmodium falciparum development / Issac et al (2012)
- Chapter 19. Impact of Genetic Modification of Vector Populations on the Malaria Eradication Agenda, by Vanessa Macias and Anthony A James / Macias et al (2015)
- MGDrivE: A modular simulation framework for the spread of gene drives through spatially-explicit mosquito populations. / Sánchez HM (2020)
- Active Genetic Neutralizing Elements for Halting or Deleting Gene Drives / Xu X.S. (2020)
- Efficient population modification gene-drive rescue system in the malaria mosquito Anopheles stephensi / A. Adolfi (2020)
- Application of the Relationship-Based Model to Engagement for Field Trials of Genetically Engineered Malaria Vectors / Kormos A. (2020)
- The origin of island populations of the African malaria mosquito, Anopheles coluzzii / Campos M, et al. (2021)
- Population modification strategies for malaria vector control are uniquely resilient to observed levels of gene drive resistance alleles / Lanzaro, G.C. et al. (2021)
- Gene Drives Gaining Speed / Bier E. (2021)
- Selection of sites for field trials of genetically engineered mosquitoes with gene drive / Lanzaro G.C. (2021)
- Cas9-mediated maternal-effect and derived resistance alleles in a gene-drive strain of the African malaria vector mosquito, Anopheles gambiae / Carballar-Lejarazú, R (2022)
- Mitogenome analyses reveal limited introduction of Anopheles coluzzii into the Central African Islands of Sao Tome and Principe. / Ditter R.E. (2022)
EXTERNAL REPORTS AND PUBLICATIONS
Links to malaria related reports and publications from international partners, organizations, and the malaria research community.
- Gene drives on the horizon: Advancing science, navigating uncertainty, and aligning research with public values / National Academies
of Science, Engineering and Medicine - Guidance framework for testing of genetically modified mosquitoes / World Health Organization
- Pathway to Deployment of Gene Drive Mosquitoes as a Potential Biocontrol Tool for Elimination of Malaria in Sub-Saharan Africa:
Recommendations of a Scientific Working Group - WHO 2019 world malaria report
- WHO Global technical strategy for malaria
- Malaria eradication: benefits, future scenarios & feasibility
- Toward the definition of efficacy and safety criteria for advancing gene drive-modified mosquitoes to field testing. / James SL, Marshall JM, Christophides GK, Okumu FO, Nolan T (2020)
- Strengthening AU Member States’ Regulatory Capacities for Responsible Research Towards Elimination of Malaria in Africa
- 2020 WHO Position Statement: Evaluation of genetically modified mosquitoes for the control of vector-borne diseases
- WHO world malaria report 2020
- WHO Guidance Framework For Testing Genetically Modified Mosquitoes, Second Edition 2021
- Proceedings of an expert workshop on community agreement for gene drive research in Africa – Co-organised by KEMRI, PAMCA and Target Malaria
- Reversing insecticide resistance with allelic-drive in Drosophila melanogaster./
B. Kaduskar, et al. (2022) - High-resolution in situ analysis of Cas9 germline transcript distributions in gene-drive Anopheles mosquitoe
s./ G. Terradas, et al. (2022)